| Item Type | Name |
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Academic Article
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Phase I safety assessment of intrathecal injection of an American formulation of adenosine in humans.
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Academic Article
|
Preliminary efficacy assessment of intrathecal injection of an American formulation of adenosine in humans.
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Academic Article
|
Intrathecal adenosine following spinal nerve ligation in rat: short residence time in cerebrospinal fluid and no change in A(1) receptor binding.
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Academic Article
|
Peripheral nerve injury alters the alpha2 adrenoceptor subtype activated by clonidine for analgesia.
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Academic Article
|
Phase I safety assessment of intrathecal ketorolac.
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Academic Article
|
Intrathecal ketorolac enhances antinociception from clonidine.
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|
Academic Article
|
Analgesia from a peripherally active kappa-opioid receptor agonist in patients with chronic pancreatitis.
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|
Academic Article
|
Intrathecal clonidine reduces hypersensitivity after nerve injury by a mechanism involving spinal m4 muscarinic receptors.
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|
Academic Article
|
Intraspinal adenosine induces spinal cord norepinephrine release in spinal nerve-ligated rats but not in normal or sham controls.
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|
Academic Article
|
Uterine cervical distension induces cFos expression in deep dorsal horn neurons of the rat spinal cord.
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Academic Article
|
Intrathecal, but not intravenous adenosine reduces allodynia in patients with neuropathic pain.
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Academic Article
|
Intrathecal injection of cAMP response element binding protein (CREB) antisense oligonucleotide attenuates tactile allodynia caused by partial sciatic nerve ligation.
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Academic Article
|
Did experimenter bias conceal the efficacy of spinal opioids in previous studies with the spinal nerve ligation model of neuropathic pain?
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Academic Article
|
Repeated dosing with oral allosteric modulator of adenosine A1 receptor produces tolerance in rats with neuropathic pain.
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Academic Article
|
The monoamine reuptake inhibitor milnacipran does not affect nociception to acute visceral distension in rats.
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Academic Article
|
Peripheral nerve injury sensitizes the response to visceral distension but not its inhibition by the antidepressant milnacipran.
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Academic Article
|
Spinal adenosine receptor activation reduces hypersensitivity after surgery by a different mechanism than after nerve injury.
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Academic Article
|
Intrathecal ketorolac in dogs and rats.
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Academic Article
|
Polyanalgesic Consensus Conference 2003: an update on the management of pain by intraspinal drug delivery-- report of an expert panel.
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Academic Article
|
Effects of laparotomy on spontaneous exploratory activity and conditioned operant responding in the rat: a model for postoperative pain.
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Academic Article
|
Intrathecal clonidine for postoperative analgesia in elderly patients: the influence of baricity on hemodynamic and analgesic effects.
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Academic Article
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Intrathecal morphine and ketorolac analgesia after surgery: comparison of spontaneous and elicited responses in rats.
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Academic Article
|
Intrathecal morphine reduces allodynia after peripheral nerve injury in rats via activation of a spinal A1 adenosine receptor.
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Academic Article
|
Intravenous butorphanol, meperidine, and their combination relieve pain and distress in women in labor.
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Academic Article
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Peripheral block of the hyperpolarization-activated cation current (Ih) reduces mechanical allodynia in animal models of postoperative and neuropathic pain.
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Academic Article
|
Clonidine maintains intrathecal self-administration in rats following spinal nerve ligation.
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Academic Article
|
Clonidine reduces hypersensitivity and alters the balance of pro- and anti-inflammatory leukocytes after local injection at the site of inflammatory neuritis.
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Academic Article
|
Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics.
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Academic Article
|
Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery.
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Academic Article
|
Brain derived nerve growth factor induces spinal noradrenergic fiber sprouting and enhances clonidine analgesia following nerve injury in rats.
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Academic Article
|
Consent contraindicated?
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Academic Article
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Role of spinal cyclooxygenase in human postoperative and chronic pain.
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Academic Article
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Effects of intrathecal ketorolac on human experimental pain.
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Academic Article
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Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming.
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Academic Article
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Up-regulation of spinal glutamate transporters contributes to anti-hypersensitive effects of valproate in rats after peripheral nerve injury.
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Academic Article
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Polyanalgesic consensus conference 2007: recommendations for the management of pain by intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel.
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Academic Article
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Dose response of intrathecal adenosine in experimental pain and allodynia.
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Academic Article
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Pharmacology of opioid inhibition to noxious uterine cervical distension.
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Academic Article
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Intrathecal ketorolac reverses hypersensitivity following acute fentanyl exposure.
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Academic Article
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Intrathecal lidocaine reverses tactile allodynia caused by nerve injuries and potentiates the antiallodynic effect of the COX inhibitor ketorolac.
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Academic Article
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Allosteric adenosine receptor modulation reduces hypersensitivity following peripheral inflammation by a central mechanism.
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Academic Article
|
Spinal adrenergic and cholinergic receptor interactions activated by clonidine in postincisional pain.
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Academic Article
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Intrathecal morphine reduces the visceromotor response to acute uterine cervical distension in an estrogen-independent manner.
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Academic Article
|
Cephalad movement of morphine and fentanyl in humans after intrathecal injection.
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Academic Article
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Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury.
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Academic Article
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Systemic, but not intrathecal ketorolac is antinociceptive to uterine cervical distension in rats.
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Academic Article
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Epidural neostigmine produces analgesia but also sedation in women after cesarean delivery.
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Academic Article
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Intrathecal but not intravenous opioids release adenosine from the spinal cord.
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Academic Article
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Spinal noradrenaline transporter inhibition by reboxetine and Xen2174 reduces tactile hypersensitivity after surgery in rats.
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Academic Article
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Perineural clonidine reduces mechanical hypersensitivity and cytokine production in established nerve injury.
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Academic Article
|
Intrathecal administration of a cylcooxygenase-1, but not a cyclooxygenase-2 inhibitor, reverses the effects of laparotomy on exploratory activity in rats.
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Academic Article
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Chronic activation of spinal adenosine A1 receptors results in hypersensitivity.
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Academic Article
|
A pain model after gynecologic surgery: the effect of intrathecal and systemic morphine.
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Academic Article
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Spinal glial activation contributes to postoperative mechanical hypersensitivity in the rat.
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Academic Article
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Analgesia induced by perineural clonidine is enhanced in persistent neuritis.
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Academic Article
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Oral donepezil reduces hypersensitivity after nerve injury by a spinal muscarinic receptor mechanism.
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|
Academic Article
|
Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil.
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|
Academic Article
|
ST91 [2-(2,6-diethylphenylamino)-2-imidazoline hydrochloride]-mediated spinal antinociception and synergy with opioids persists in the absence of functional alpha-2A- or alpha-2C-adrenergic receptors.
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Academic Article
|
Assessment of behavior during labor in rats and effect of intrathecal morphine.
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Academic Article
|
Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards.
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Academic Article
|
Multiplicative interactions to enhance gabapentin to treat neuropathic pain.
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|
Academic Article
|
The effect of peripherally administered CDP-choline in an acute inflammatory pain model: the role of alpha7 nicotinic acetylcholine receptor.
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|
Academic Article
|
Activation of glutamate transporters in the locus coeruleus paradoxically activates descending inhibition in rats.
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|
Academic Article
|
The need for a journal policy on intrathecal, epidural, and perineural administration of non-approved drugs.
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|
Academic Article
|
Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat.
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|
Academic Article
|
Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors.
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|
Academic Article
|
Oxytocin inhibits the membrane depolarization-induced increase in intracellular calcium in capsaicin sensitive sensory neurons: a peripheral mechanism of analgesic action.
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|
Academic Article
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Reversal of peripheral nerve injury-induced hypersensitivity in the postpartum period: role of spinal oxytocin.
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|
Academic Article
|
Predicting acute pain after cesarean delivery using three simple questions.
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Concept
|
Bicuculline
|
|
Concept
|
Aconitine
|
|
Concept
|
Pyridines
|
|
Concept
|
Somatostatin
|
|
Concept
|
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
|
|
Concept
|
Adrenergic alpha-Antagonists
|
|
Concept
|
Cystatin C
|
|
Concept
|
Nicotinic Agonists
|
|
Concept
|
Estradiol
|
|
Concept
|
Piroxicam
|
|
Concept
|
Substance P
|
|
Concept
|
Anesthetics, Local
|
|
Concept
|
Oxytocics
|
|
Concept
|
Quinolizines
|
|
Concept
|
Cyclic AMP Response Element-Binding Protein
|
|
Concept
|
Lidocaine
|
|
Concept
|
Ketamine
|
|
Concept
|
Sulfur Isotopes
|
|
Concept
|
Acetylcholine
|
|
Concept
|
Neostigmine
|
|
Concept
|
Neurotoxins
|
|
Concept
|
Kainic Acid
|
|
Concept
|
Isoindoles
|
|
Concept
|
Norepinephrine
|
|
Concept
|
Green Fluorescent Proteins
|
|
Concept
|
Ondansetron
|
|
Concept
|
Organophosphorus Compounds
|
|
Concept
|
Calcium-Binding Proteins
|
|
Concept
|
Anesthetics
|
|
Concept
|
Plant Proteins
|
|
Concept
|
Glutamate Decarboxylase
|
|
Concept
|
Metoprolol
|
|
Concept
|
Oligonucleotides, Antisense
|
|
Concept
|
Anesthetics, Dissociative
|
|
Concept
|
N-Methylaspartate
|
|
Concept
|
Food
|
|
Concept
|
Amines
|
|
Concept
|
Excitatory Amino Acid Transporter 1
|
|
Concept
|
Glial Fibrillary Acidic Protein
|
|
Concept
|
Phosphodiesterase Inhibitors
|
|
Concept
|
Ligands
|
|
Concept
|
Theobromine
|
|
Concept
|
Receptors, Purinergic P2
|
|
Concept
|
Receptors, Cholinergic
|
|
Concept
|
Choline O-Acetyltransferase
|
|
Concept
|
Butorphanol
|
|
Concept
|
Ectodysplasins
|
|
Concept
|
Bronchodilator Agents
|
|
Concept
|
Dopamine beta-Hydroxylase
|
|
Concept
|
Sucrose
|
|
Concept
|
Receptors, Serotonin, 5-HT3
|
|
Concept
|
Calcium
|
|
Concept
|
TRPV Cation Channels
|
|
Concept
|
Analgesics, Opioid
|
|
Concept
|
Injections, Spinal
|
|
Concept
|
Bisoprolol
|
|
Concept
|
Opioid Peptides
|
|
Concept
|
Tachykinins
|
|
Concept
|
Yohimbine
|
|
Concept
|
Lipopolysaccharides
|
|
Concept
|
Guanosine Triphosphate
|
|
Concept
|
Cyclohexanols
|
|
Concept
|
Anti-Inflammatory Agents, Non-Steroidal
|
|
Concept
|
Adrenergic Uptake Inhibitors
|
|
Concept
|
Thiophenes
|
|
Concept
|
Dynorphins
|
|
Concept
|
Pyrimidines
|
|
Concept
|
Excitatory Amino Acid Transporter 2
|
|
Concept
|
Drug Interactions
|
|
Concept
|
Amides
|
|
Concept
|
Oxytocin
|
|
Concept
|
Dose-Response Relationship, Drug
|
|
Concept
|
Caspase 3
|
|
Concept
|
Zymosan
|
|
Concept
|
Fura-2
|
|
Concept
|
Indans
|
|
Concept
|
Aminophylline
|
|
Concept
|
Vasotocin
|
|
Concept
|
Sodium
|
|
Concept
|
Tritium
|
|
Concept
|
Cyclooxygenase 2
|
|
Concept
|
Valproic Acid
|
|
Concept
|
Receptors, Oxytocin
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|
Concept
|
Excitatory Amino Acid Antagonists
|
|
Concept
|
Receptors, Metabotropic Glutamate
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|
Concept
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Cysteine
|
|
Concept
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Idazoxan
|
|
Concept
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Atropine
|
|
Concept
|
Lipids
|
|
Concept
|
Drug Evaluation, Preclinical
|
|
Concept
|
gamma-Aminobutyric Acid
|
|
Concept
|
Carrageenan
|
|
Concept
|
Isoenzymes
|
|
Concept
|
Cyclooxygenase 2 Inhibitors
|
|
Concept
|
Receptors, Prostaglandin E
|
|
Concept
|
Receptors, Purinergic P1
|
|
Concept
|
HIV Envelope Protein gp120
|
|
Concept
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Immunotoxins
|
|
Concept
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Receptors, Muscarinic
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|
Concept
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Drug Hypersensitivity
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|
Concept
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Adjuvants, Anesthesia
|
|
Concept
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Antihypertensive Agents
|
|
Concept
|
Tumor Necrosis Factor-alpha
|
|
Concept
|
Dinoprostone
|
|
Concept
|
Citrates
|
|
Concept
|
Receptors, Glutamate
|
|
Concept
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Estrogens
|
|
Concept
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Indole Alkaloids
|
|
Concept
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Serotonin Antagonists
|
|
Concept
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Prilocaine
|
|
Concept
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Anti-Inflammatory Agents
|
|
Concept
|
Receptors, Opioid, mu
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|
Concept
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Oxyhemoglobins
|
|
Concept
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Receptors, Nicotinic
|
|
Concept
|
Bee Venoms
|
|
Concept
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Fentanyl
|
|
Concept
|
Transforming Growth Factor beta1
|
|
Concept
|
Receptors, GABA-B
|
|
Concept
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Neurotransmitter Uptake Inhibitors
|
|
Concept
|
Adenosine
|
|
Concept
|
Guanosine 5'-O-(3-Thiotriphosphate)
|
|
Concept
|
Drug Synergism
|
|
Concept
|
Nicotinic Antagonists
|
|
Concept
|
Receptor, Adenosine A1
|
|
Concept
|
CREB-Binding Protein
|
|
Concept
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Drug Administration Routes
|
|
Concept
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RNA, Messenger
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|
Concept
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Naltrexone
|
|
Concept
|
Parasympatholytics
|
|
Concept
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Cytokines
|
|
Concept
|
Membrane Proteins
|
|
Concept
|
Bupivacaine
|
|
Concept
|
Hormone Antagonists
|
|
Concept
|
Receptors, Opioid, kappa
|
|
Concept
|
N-Glycosyl Hydrolases
|
|
Concept
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Apoptosis
|
|
Concept
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Drug Administration Schedule
|
|
Concept
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Protein Subunits
|
|
Concept
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Narcotics
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|
Concept
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Muscarinic Antagonists
|
|
Concept
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DNA-Binding Proteins
|
|
Concept
|
Cyclooxygenase Inhibitors
|
|
Concept
|
RNA, Small Interfering
|
|
Concept
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Morphine
|
|
Concept
|
Anesthetics, Intravenous
|
|
Concept
|
Adrenergic alpha-Agonists
|
|
Concept
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Drug Compounding
|
|
Concept
|
Methadone
|
|
Concept
|
Injections, Epidural
|
|
Concept
|
Prostaglandin-Endoperoxide Synthases
|
|
Concept
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Azetidines
|
|
Concept
|
Ketorolac
|
|
Concept
|
Glutamic Acid
|
|
Concept
|
Amino Acid Transport System X-AG
|
|
Concept
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Sodium Chloride
|
|
Concept
|
Ion Channels
|
|
Concept
|
Neurofilament Proteins
|
|
Concept
|
Cholinergic Agents
|
|
Concept
|
p38 Mitogen-Activated Protein Kinases
|
|
Concept
|
Drug Tolerance
|
|
Concept
|
Drug Therapy, Combination
|
|
Concept
|
Parasympathomimetics
|
|
Concept
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Riluzole
|
|
Concept
|
Receptor, Muscarinic M4
|
|
Concept
|
Nitric Oxide
|
|
Concept
|
Cholinesterase Inhibitors
|
|
Concept
|
Fluorescent Dyes
|
|
Concept
|
Imidazoles
|
|
Concept
|
Cystatins
|
|
Concept
|
Xanthines
|
|
Concept
|
Pyrazoles
|
|
Concept
|
Mecamylamine
|
|
Concept
|
Narcotic Antagonists
|
|
Concept
|
Drug Approval
|
|
Concept
|
Atenolol
|
|
Concept
|
Naloxone
|
|
Concept
|
Dizocilpine Maleate
|
|
Concept
|
Elapid Venoms
|
|
Concept
|
GABA Agents
|
|
Concept
|
Amitriptyline
|
|
Concept
|
Cyclopropanes
|
|
Concept
|
Injections
|
|
Concept
|
Heroin
|
|
Concept
|
Indoles
|
|
Concept
|
Peptides
|
|
Concept
|
GTP-Binding Proteins
|
|
Concept
|
Receptor, Cannabinoid, CB2
|
|
Concept
|
Transcription Factors
|
|
Concept
|
Cyclohexanes
|
|
Concept
|
Meperidine
|
|
Concept
|
Cyclohexanecarboxylic Acids
|
|
Concept
|
Receptor, Nerve Growth Factor
|
|
Concept
|
Drosophila Proteins
|
|
Concept
|
Chemokine CCL2
|
|
Concept
|
Memantine
|
|
Concept
|
Microfilament Proteins
|
|
Concept
|
S-Nitrosothiols
|
|
Concept
|
Nitric Oxide Synthase Type I
|
|
Concept
|
Calcitonin Gene-Related Peptide
|
|
Concept
|
Hydromorphone
|
|
Concept
|
Corticosterone
|
|
Concept
|
Succinate Dehydrogenase
|
|
Concept
|
Cytidine Diphosphate Choline
|
|
Concept
|
Desipramine
|
|
Concept
|
Tyrosine 3-Monooxygenase
|
|
Concept
|
Aziridines
|
|
Concept
|
Analgesics, Non-Narcotic
|
|
Concept
|
Enzyme Inhibitors
|
|
Concept
|
Proto-Oncogene Proteins c-fos
|
|
Concept
|
Analgesics
|
|
Concept
|
Clonidine
|
|
Concept
|
Anesthetics, Combined
|
|
Concept
|
Neuromuscular Blocking Agents
|
|
Concept
|
Theophylline
|
|
Concept
|
Nitric Oxide Donors
|
|
Concept
|
Central Nervous System Agents
|
|
Concept
|
Piperidines
|
|
Concept
|
Morpholines
|
|
Concept
|
Capsaicin
|
|
Concept
|
Sulfonamides
|
|
Concept
|
Phenols
|
|
Concept
|
GABA Antagonists
|
|
Concept
|
Ribosome Inactivating Proteins, Type 1
|
|
Concept
|
Proton Pumps
|
|
Concept
|
Nitrobenzenes
|
|
Concept
|
Nootropic Agents
|
|
Concept
|
Receptors, Vasopressin
|
|
Concept
|
Sensory System Agents
|
|
Concept
|
Sulfamethizole
|
|
Concept
|
Choline
|
|
Concept
|
Nerve Tissue Proteins
|
|
Concept
|
Drug Combinations
|
|
Concept
|
Receptors, Adrenergic, alpha-2
|
|
Concept
|
Cyclooxygenase 1
|
|
Concept
|
Injections, Intravenous
|
|
Concept
|
Antidepressive Agents
|
|
Concept
|
Brain-Derived Neurotrophic Factor
|
|
Concept
|
Carbazoles
|
|
Concept
|
Prostaglandins
|
|
Academic Article
|
Preclinical toxicity screening of intrathecal oxytocin in rats and dogs.
|
|
Academic Article
|
Gabapentin increases extracellular glutamatergic level in the locus coeruleus via astroglial glutamate transporter-dependent mechanisms.
|
|
Academic Article
|
Phase 1 safety assessment of intrathecal oxytocin.
|
|
Academic Article
|
Failure of intrathecal ketorolac to reduce remifentanil-induced postinfusion hyperalgesia in humans.
|
|
Academic Article
|
Intrathecal clonidine and adenosine: effects on pain and sensory processing in patients with chronic regional pain syndrome.
|
|
Academic Article
|
Reporting of Preclinical Research in Anesthesiology: Transparency and Enforcement.
|
|
Grant
|
EPIDURAL CLONIDINE ANALGESIA IN OBSTETRICS
|
|
Grant
|
Receptor Selective Spinal Analgesia
|
|
Grant
|
Spinal Noradrenergic Sprouting after Nerve Injury
|
|
Grant
|
EPIDURAL CLONIDINE ANALGESIA IN OBSTETRICS
|
|
Grant
|
SEX DIFFERENCES IN CHOLINERGIC MEDIATED ANALGESIA
|
|
Grant
|
Receptor Selective Spinal Analgesia
|
|
Grant
|
Pharmacologic Plasticity in the Presence of Pain
|
|
Grant
|
Alpha2-Adrenergic Analgesia
|
|
Academic Article
|
Assessment of Behavioral Disruption in Rats with Abdominal Inflammation Using Visual Cue Titration and the Five-choice Serial-reaction Time Task.
|
|
Academic Article
|
Plasticity and Function of Spinal Oxytocin and Vasopressin Signaling during Recovery from Surgery with Nerve Injury.
|
|
Academic Article
|
Spinal Exparel®-an extended duration of preclinical study needed.
|